2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. GABA Receptor

GABA Receptor

Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor

GABA Receptor

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GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-A0173R
    Progabide (Standard)
    		Agonist
    Progabide (Standard) is the analytical standard of Progabide. This product is intended for research and analytical applications. Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.
    Progabide (Standard)
  • HY-106025R
    Radequinil (Standard)
    		Antagonist
    Radequinil (Standard) is the analytical standard of Radequinil (HY-106025). This product is intended for research and analytical applications. Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively.
    Radequinil (Standard)
  • HY-128469
    Inaperisone
    		99.0%
    Inaperisone is a centrally acting muscle relaxant. Inaperisone can inhibit the micturition reflex by acting indirectly on GABAB receptors in the brainstem.
    Inaperisone
  • HY-B0353R
    Chlormezanone (Standard)
    Chlormezanone (Standard) is the analytical standard of Chlormezanone. This product is intended for research and analytical applications. Chlormezanone resembles benzodiazepine. The action of Chlormezanone is similar to benzodiazepine-type agents. Chlormezanone is used as an anxiolytic and a muscle relaxant.
    Chlormezanone (Standard)
  • HY-124463S1
    Epiallopregnanolone-d5
    		Antagonist
    Epiallopregnanolone-d5 (5α,3β-THDOC-d5) is deuterium labeled Epiallopregnanolone. Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer.
    Epiallopregnanolone-d<sub>5</sub>
  • HY-N0700R
    alpha-Asarone (Standard)
    		Activator
    alpha-Asarone (Standard) is the analytical standard of alpha-Asarone. This product is intended for research and analytical applications. alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.
    alpha-Asarone (Standard)
  • HY-W291165
    D-DABA
    		Inhibitor
    D-DABA is the enantiomeric form of L-DABA. D-DABA is also a weak inhibitor of GABA-T, but which has only one twentieth of the potency of the L-isomer in inhibiting GABA uptake.
    D-DABA
  • HY-119687R
    Bifenazate (Standard)
    		Agonist
    Bifenazate (Standard) is the analytical standard of Bifenazate. This product is intended for research and analytical applications. Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm. Bifenazate is a positive allosteric modulator of GABA receptor. Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III.
    Bifenazate (Standard)
  • HY-B0122S1
    Topiramate-13C
    		Activator
    Topiramate-13C (McN 4853-13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate-<sup>13</sup>C<sub>
  • HY-120276
    Golexanolone
    		Antagonist
    Golexanolone is a GABAA receptor modulating steroid antagonist. Golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats.
    Golexanolone
  • HY-114685
    S-8510 free base
    		Antagonist
    S-8510 free base is an inverse Benzodiazepine (BDZ) receptor agonist, with Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively.
    S-8510 free base
  • HY-101869R
    MK-0343 (Standard)
    		Agonist
    MK-0343 (Standard) is the analytical standard of MK-0343. This product is intended for research and analytical applications. MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic.
    MK-0343 (Standard)
  • HY-105567
    Carbiphene
    		Antagonist
    Carbiphene is a GABAA receptor allosteric modulator. Carbiphene inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene can be used in research related to schizophrenia.
    Carbiphene
  • HY-W644305
    Androst-16-en-3-ol
    		Modulator
    Androst-16-en-3-ol is a pheromone derived from boars that triggers mating responses in estrous sows. It also exists in human urine, plasma, saliva and sweat. As an endogenous neurosteroid, Androst-16-en-3-ol acts as a positive allosteric modulator of GABAA receptors (GABAA receptor) and exerts anxiolytic, antidepressant and anticonvulsant activities in mice.
    Androst-16-en-3-ol
  • HY-101639AR
    CP-409092 hydrochloride (Standard)
    		Agonist
    CP-409092 (hydrochloride) (Standard) is the analytical standard of CP-409092 (hydrochloride) (HY-101639A). This product is intended for research and analytical applications. CP-409092 hydrochloride is a partial agonist of GABAA receptor, with anti-anxiety activity.
    CP-409092 hydrochloride (Standard)
  • HY-11065A
    (iodo-125)-CGP 71872
    		Antagonist
    (iodo-125)-CGP 71872 is a iodo-125-labeled CGP 71872 (GABABR1 receptor agonist),containing an azido group that can be photoactivated,and can be used to characterize GABAB receptors.
    (iodo-125)-CGP 71872
  • HY-100686R
    U93631 (Standard)
    		Inhibitor
    U93631 (Standard) is the analytical standard of U93631 (HY-100686). This product is intended for research and analytical applications. 0
    U93631 (Standard)
  • HY-105056R
    Bretazenil (Standard)
    		Agonist
    Bretazenil (Standard) is the analytical standard of Bretazenil (HY-105056). This product is intended for research and analytical applications. Bretazenil (Ro 16-6028) is a partial agonist at the gamma-aminobutyric acid A (GABAA) receptor-linked benzodiazepine site. Bretazenil is potent benzodiazepine examined, exhibiting an IC50 (concentration at which half-maximal inhibition of specific [35S]TBPS binding occurs) of 6.1 nM. Bretazenil shows an EC50 of 10 nM for recombinant α1β1γ2. Anticonvulsant effects.
    Bretazenil (Standard)
  • HY-14843
    Imagabalin
    Imagabalin (PD-0332334 free base) is an active compound with activity for studying neurological diseases. The synthesis of imagabalin involves the reaction of 3-methylvaleric acid and Meldrum acid. During the synthesis of imagabalin, an acyl chloride intermediate species, 3-methylvaleryl chloride, was revealed for the first time. The synthesis of imagabalin also provided new information about the reaction mechanism, indicating that 3-methylvaleric anhydride is an important intermediate.
    Imagabalin
  • HY-106875
    Saripidem
    		Modulator
    Saripidem is a non-selective ligand for ω modulatory sites of GABA receptor.
    Saripidem
Cat. No. Product Name / Synonyms Application Reactivity